Dopamine, Serotonin, Norepinephrine and mood

Gastroenterology is the branch of medicine whereby the digestive system and its disorders are studied. Many conditions such as Crohn’s, colitis, celiac, are related to autoimmune system activation in which a leaky gut may play a role.  Other conditions such as Attention defecit, bipolar, depression, autism, multiple sclerosis, chronic fatigue, fibromyalgia, anxiety, POTS and chronic lyme may be related to chemical metabolisms problems which may be a part of enzyme defects in the methyl cycle, folic cycle, methionine cycle, detox cycle- which occurs in numerous cells throughout the body.
Defects in certain enzymes lead to neurotransmitter problems of dopamine, norepinephrine, and serotonin- seen in panic attacks, anxiety, attention defecit hyperactivity, parkinson,s ( a dopamine problem), Alzheimer’s ( a  possible detoxification problem in the brain associated with metals)
Chronic lyme and its associated coinfections- may be continuous activation of the immune system by live infection, chemicals elicited as a result of this infection may worsen the condition and even perpetuate the symptoms. Having a biochemical understanding of the enzymes involved – which is unique to each individual might help tailor a treatment that is for that person based on their  genes, dna, enzymes and their own response to the conditions which initiated their illness. This premise is true for other autoimmune diseases such as celiac, crohn’s colitis, multiple sclerosis, autoimmune thyroid disease

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mthfr DEFECTS AND THE EFFICIENCY OF THE ENZYME

1298 AND 677 ENZYME DEFECTS AND DECREASED mthfr ENZYME EFFICIENCY

this ILNK ABOVE EXPALINS WHY PEOPLE WITH mthfr DEFECTS HAVE PROBLEMS CONVERTING folic acid to active 5-L-methryfolate. THe reduced enzyme activity as a result of these gene mutations affects the whole methylation and folic acid cycle. Its an explanation for abortions( not enough methylfolate and possible neural tube defects). Its a consideration in affecting the immune system,. It plays a role in neurotransmitter dopamine, serotonin and neurepinephrine chemicals in patients with lyme, chronic fatigue, fibromyalgia, anxiety, panic, bipolar, depression. In its association with immune system and detoxification, it plays a role in alzheimers, parkinsons, and many other degernerative diseases such as heart attack risk , stroke, blood clots ( which are related to homocysteine levels, methionine and b12 and folic acid)

for more info- http://www.healthydays.info/mthfr.html

for videos on MTHFR go to MTHFR and folic acid video
MTHFR and pregnancy video
MTHFR testing labs information
MTHFR test results video
MTHFR gene defects video
– See more at: http://www.healthydays.info/specialties.html#sthash.oSnOGGE2.dpuf

Leaky GUT

Leaky Gut could be implicated as a primary contributor to asthma, food allergies, chronic sinusitis, eczema, rashes, migraine, irritable bowel, fungal disorders, fibromyalgia, and inflammatory joint disorders including rheumatoid arthritis. It also contributes to chronic fatigue, crohn’s, celiac,thyroiditis, ulcerative colitis and other autoimmune conditions. Conditions associated with leaky gut include malnutrition, intestinal infections, autism, steroid drug use, parasites, excessive use of antibiotics and yeast overgrowth.

 

There’s no miracle cure for treating leaky gut, but there are things you can do if you’re suffering from it that can help heal inflammation and restore the integrity of your gut lining.

An anti-inflammatory diet that eliminates refined sugars, dairy, gluten, alcohol and artificial sweeteners – some of the biggest offenders when it comes to inflammation – can be very helpful. Consuming lots of anti-inflammatory essential fatty acids in fish and nuts, and filling up on green leafy vegetables, high-fiber and fermented foods that help to promote the growth of good bacteria is also crucial.

A robust probiotic that contains large amounts of good bacteria can help heal a damaged intestinal lining by restoring balance in the gut flora.

Supplements like glutamine have been shown in some studies to help with intestinal injury after chemotherapy and radiation and may be beneficial in leaky gut.

Most people will notice improvement within 6 weeks, although it may take several months and even years to heal a damaged intestinal lining in extreme cases of leaky gut. Because we’re still learning about leaky gut, many of the treatment guidelines are drawn more from anecdotal observation than from rigorous scientific studies. But they’re sensible recommendations that can lead to improvements in your overall health, whether or not you have increased intestinal permeability.

Leaky gut is one of those diagnoses that bridges the gap between conventional and alternative medicine, between what we can see and touch and what we can feel in our bodies. I refuse to believe that the hundreds of patients I see in my office with unusual and seemingly unrelated complaints are crazy, or just stressed out.

I believe them when they say they feel like they’re being poisoned, or that they think there’s a connection between all their symptoms, even though they don’t know what it is. My hunch is that as our knowledge grows, the theories behind leaky gut will become the foundation for lots of diseases that are widely prevalent in our society, and millions of people will be in a better position to find relief from their suffering.

Leaky Gut and its consequences- Is Yeast overgrowth the only cause?

In Leaky Gut Syndrome, the lining of the small intestine becomes inflamed and irritated allowing metabolic and microbial toxins normally kept within the small intestines for passage into the colon to enter the blood stream.

Leaky Gut could be implicated as a primary contributor to asthma, food allergies, chronic sinusitis, eczema, rashes, migraine, irritable bowel, fungal disorders, fibromyalgia, and inflammatory joint disorders including rheumatoid arthritis. It also contributes to PMS, uterine fibroid, breast fibroids, chronic fatigue syndrome and pediatric immune deficiencies.

Leaky Gut Syndrome is a very common problem of modern society in part because of antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), like Motrin, Advil, Aleve, which damage the natural balance the bowel requires to operate optimally.

 

Antibiotics damage the bowel environment in two ways. The first is by destroying beneficial bacteria.

The second way antibiotics damage the intestines is by promoting the growth of Candida and other fungi and yeast. Candida overgrowth may precipitate Leaky Gut Syndrome

 

The damage done by Candida is to the intestinal epithelial barrier, allowing the absorption of toxins and chemicals to enter the blood and affect numerous organs, including the brain

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With leaky gut, nutrients can be absorbed before they are fully digested. The body’s immune response, through specific antigen-antibody markers (the food IgG test), will identify some of these foods as foreign invaders. Every time that particular food contacts the lining of the intestines, an inflammatory immune response is mounted that further damages the epithelial lining Food “allergies” may become a common secondary contributor to maintaining the leaky gut, even after the yeast is eradicated.

 

The most common food allergies are dairy, eggs, gluten grains (wheat, barley,oats, rye), corn, beans (especially soy), and nuts. It is uncommon to have an allergy to meat, rice, millet, vegetables, or fruit. When an IgG antibody to a food is detected, it is important distinguish a real allergy – that which causes an inflammatory reaction.

 

 

 

While lactobacillus supplementation is often recommended to help with leaky gut and Candida overgrowth, most of the lactobacillus sold today does not survive in the intestine, either due to poor terrain or due to being a strain that does not implant in the human intestines. There are specific Lactobacillus preparations available that do implant and do help establish a healthy intestinal environment.

 

Summary of Common Causes of Leaky Gut Syndrome:

Consumption of allergenic foods

For infants, premature birth

Inflammatory Bowel Disease

Radiation therapy

Alcohol consumption (depletes N-acetyl glucosamine)

Non-steroidal anti-inflammatory ( depletes N-acetyl glucosamine)

Steroids (prednisone, Medrol, cortisone, etc.)

Deficiencies of amino acids that support the gastrointestinal lining (glutamine, arginine, taurine, BCAA, etc.)

Zinc or vitamin A deficiency

Digestive tract infections (bacteria, yeast, parasites, viruses)

Excessive stress

Poor digestion

Starvation

Antibiotics

Excessive sugar leading to yeast and bacterial overgrowth

HIV infection